COMPUTATION OF THE HYDROPHOBICITY PARAMETER (EACN) OF OIL PHASE INGREDIENTS ESSENTIAL FOR PREDICTING PROPERTIES OF MICROEMULSIONS USING THE HLD-NAC THEORY
DOI:
https://doi.org/10.26408/137.05Keywords:
hydrophobicity parameter, fragrance compounds, perfumery raw materials, microemulsions, HLD-NAC theoryAbstract
In this work we describe in detail our novel computation method for predicting the EACN hydrophobicity parameter of hydrophobic compounds, which is used in the HLD equation developed by Salager. The values of EACN obtained in such a way can be applied to predict the phase equilibria in emulsions or microemulsions as well as various physicochemical properties describing these systems by means of the HLD-NAC theory. Application of the HLD-NAC theory as a predictive tool for excipients used in cosmetic or pharmaceutical products may enable the rational design of new products based on emulsions or microemulsions, eliminating in practice the need for many problem-solving efforts and long-term product development. The computed values of the EACN were compared with the experimental data published in the literature for 141 hydrophobic compounds. We have found that the computation method described in this work applied to various hydrophobic compounds leads to the numerical values of the EACN being in a very good agreement with the corresponding experimental values published in the literature. It should be noted, however, that the proposed method is not suitable for predicting EACN values of triglycerides and edible oils.
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Copyright (c) 2026 RYSZARD ZIELINSKI, Sebastian Grzyb
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